In contrast to small molecule drugs, which are chemically synthesized, biologics and biosimilars, also known as biotherapeutic drugs, are produced from living organisms such as bacteria, yeast and mammalian cells.

NMR is ideally suited for similarity assessment of biologics and biosimilars. NMR allows for intact protein analysis, enabling structural evaluation of therapeutic drugs without modification, in conditions that are physiologically relevant. Learn more about Bruker’s solutions for Biologics and Biosimilars below.

Biotherapeutics Characterization Hub

Discover our virtual hub Advancing Biotherapeutics Characterization with Magnetic Resonance: on one page you can easily access webinars and articles from pharma key opinion leaders and find new solutions for the quality assessment of biologics and biosimilars at atomic resolution.

Utility of High Resolution 2D NMR Fingerprinting in Assessing Viscosity of Therapeutic Monoclonal Antibodies

Scientist at Pfizer show that early transients to Fab-Fab or Fab-Fc interactions manifest through peak broadening or peak shift in the 2D NMR spectrum of mAb/mAb fragments at 900 MHz. Such insights go beyond rank ordering mAbs based on viscosity behaviour obtained by other methods.

On Demand Webinar: NMR Spectroscopy for Robust Assessment of the Higher Order Structure of Biologics

During this talk, Dr. Ashutosh Kumar, Professor from the Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, demonstrates the applicability of high-resolution NMR techniques to understand the higher order structure of biopharmaceuticals in their formulated states.

Bruker Arxspan BioDrive: Free Trial

Are you working on molecular biology and sequencing topics?  Arxspan's BioDrive molecular biology software provides full coverage for biologists including molecular biology, assay development, screening, analysis, bioanalytical and bioprocess research. Get your free trial today!